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The 12 principles of Green Chemistry (Anastas and Warner):

  1. Prevention: it is better to prevent waste than to treat or clean it up after it is formed.
  2. Atom economy: design syntheses so that as many atoms of the reactants as possible end up in the product.
  3. Less hazardous chemical syntheses: use and generate substances of little or no toxicity.
  4. Designing safer chemicals: products should do their job while being minimally toxic.
  5. Safer solvents and auxiliaries: avoid them where possible, or use harmless ones (water, supercritical CO2, ionic liquids).
  6. Design for energy efficiency: run reactions at ambient temperature and pressure where possible.
  7. Use of renewable feedstocks in place of depleting ones.
  8. Reduce derivatives: avoid unnecessary blocking/protecting groups.
  9. Catalysis: selective catalytic reagents are better than stoichiometric reagents.
  10. Design for degradation: products should break down into harmless substances after use.
  11. Real-time analysis for pollution prevention: monitor processes in-process to stop hazardous substances forming.
  12. Inherently safer chemistry for accident prevention: choose substances that reduce the risk of explosions, fires and releases.
Doubtly AI · 25 Oct 2026 AI-verified · Oct 2026 Report
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