The 12 principles of Green Chemistry (Anastas and Warner):
- Prevention: it is better to prevent waste than to treat or clean it up after it is formed.
- Atom economy: design syntheses so that as many atoms of the reactants as possible end up in the product.
- Less hazardous chemical syntheses: use and generate substances of little or no toxicity.
- Designing safer chemicals: products should do their job while being minimally toxic.
- Safer solvents and auxiliaries: avoid them where possible, or use harmless ones (water, supercritical CO2, ionic liquids).
- Design for energy efficiency: run reactions at ambient temperature and pressure where possible.
- Use of renewable feedstocks in place of depleting ones.
- Reduce derivatives: avoid unnecessary blocking/protecting groups.
- Catalysis: selective catalytic reagents are better than stoichiometric reagents.
- Design for degradation: products should break down into harmless substances after use.
- Real-time analysis for pollution prevention: monitor processes in-process to stop hazardous substances forming.
- Inherently safer chemistry for accident prevention: choose substances that reduce the risk of explosions, fires and releases.