Which one of the following statements is correct, with reference to enzymes ?
1. Holoenzyme = Apoenzyme + Coenzyme
2. Coenzyme = Apoenzyme + Holoenzyme
3. Holoenzyme = Coenzyme + Co-factor
4. Apoenzyme = Holoenzyme + Coenzyme
1. Holoenzyme = Apoenzyme + Coenzyme
2. Coenzyme = Apoenzyme + Holoenzyme
3. Holoenzyme = Coenzyme + Co-factor
4. Apoenzyme = Holoenzyme + Coenzyme
Best answer
Answer: 1. Holoenzyme = Apoenzyme + Coenzyme
Key idea: An active conjugated enzyme has a protein part and a non-protein part.
The protein part is the apoenzyme. The non-protein part is the cofactor, which may be a coenzyme (organic), a prosthetic group or a metal ion. Apoenzyme + cofactor gives the active holoenzyme. Among the options, only (1) puts the terms in a valid relation; in the others a whole is shown as a part of itself or a part as a sum. Answer: (1).
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