Topic: Cell cycle, mitosis, meiosis· Cell Structure and Function

Anaphase Promoting Complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur ?

1. Chromosomes will be fragmented

2. Chromosomes will not segregate

3. Recombination of chromosome arms will occur

4. Chromosomes will not condense

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Answer: 2. Chromosomes will not segregate

Key idea: APC degrades securin so that separase can cut cohesin between sister chromatids at the metaphase-anaphase transition.

If APC is defective, cohesin is not cleaved, and the sister chromatids stay together: chromosomes will not segregate. Fragmentation, recombination and condensation do not depend on APC. Answer: (2).

Doubtly AI · 30 Oct 2026 AI-generated · not yet verified Report

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Anaphase Promoting Complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur ?

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