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Answer: 1. Hoffmann hypobromamide reaction

Key idea: Hoffmann bromamide reaction removes one carbon from an amide to give a primary amine.

\(CH_3CONH_2 + Br_2 + 4NaOH \rightarrow CH_3NH_2 + Na_2CO_3 + 2NaBr + 2H_2O\). Acetamide (2 C) gives methanamine (1 C). Gabriel synthesis and the carbylamine reaction do not use amides this way, and Stephen's reaction reduces nitriles to aldehydes.

Doubtly AI · 30 Oct 2026 AI-generated · not yet verified Report
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