The association of histone H1 with a nucleosome indicates :
1. DNA replication is occurring.
2. The DNA is condensed into a Chromatin Fibre.
3. The DNA double helix is exposed.
4. Transcription is occurring.
1. DNA replication is occurring.
2. The DNA is condensed into a Chromatin Fibre.
3. The DNA double helix is exposed.
4. Transcription is occurring.
Best answer
Answer: 2. The DNA is condensed into a Chromatin Fibre.
Key idea: Histone H1 is the linker histone that seals the nucleosome.
H1 binds the linker DNA where it enters and leaves the nucleosome and pulls nucleosomes together, so the beads-on-a-string fibre folds into a condensed chromatin fibre. Condensation makes DNA less accessible, so replication or transcription is not occurring, and the helix is not exposed. Answer: (2).
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