Thalassemia and sickle cell anemia are caused due to a problem in globin molecule synthesis. Select the correct statement.

1. Both are due to a quantitative defect in globin chain synthesis.

2. Thalassemia is due to less synthesis of globin molecules.

3. Sickle cell anemia is due to a quantitative problem of globin molecules.

4. Both are due to a qualitative defect in globin chain synthesis.

Doubtly Asked 30 Oct 2026 NEET UG 2017 Practice test neet Save WhatsApp Report

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Answer: 2. Thalassemia is due to less synthesis of globin molecules.

Key idea: The two disorders differ in the type of globin defect.

Thalassemia: a quantitative defect; too little of the \(\alpha\) or \(\beta\) globin chain is made (due to mutation or deletion).
Sickle cell anaemia: a qualitative defect; a point mutation (Glu to Val at position 6 of the \(\beta\) chain) gives an abnormal haemoglobin.

Thus only statement (2) is correct. Answer: (2).

Doubtly AI · 30 Oct 2026 AI-generated · not yet verified Report

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