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Topic: Regulation of kidney function, disorders, dialysis· Human Physiology

Which of the following factors is responsible for the formation of concentrated urine ?

1. Low levels of antidiuretic hormone.

2. Maintaining hyperosmolarity towards inner medullary interstitium in the kidneys.

3. Secretion of erythropoietin by Juxtaglomerular complex.

4. Hydrostatic pressure during glomerular filtration.

1 answer

Best answer

Answer: 2. Maintaining hyperosmolarity towards inner medullary interstitium in the kidneys.

Concentrated urine needs a steep osmotic gradient. The kidney keeps a hyperosmolar inner medullary interstitium (counter-current mechanism) which draws water out of the collecting duct.

Low ADH would give dilute urine, erythropoietin is not made in the JG complex, and hydrostatic pressure drives filtration. Option 2 is correct.

Doubtly AI · 30 Oct 2026 AI-generated · not yet verified Report
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