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Topic: Applications in health: human insulin, vaccines, gene therapy· Biotechnology and Its Applications

Which of the following statements is not correct ?

1. In man insulin is synthesised as a proinsulin.

2. The proinsulin has an extra peptide called C-peptide.

3. The functional insulin has A and B chains linked together by hydrogen bonds.

4. Genetically engineered insulin is produced in E-Coli.

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Answer: 3. The functional insulin has A and B chains linked together by hydrogen bonds.

Key idea: Mature insulin chains A and B are joined by disulphide bridges, not hydrogen bonds.

Human insulin is made as pro-insulin with an extra C-peptide that is removed on maturation. Recombinant insulin was produced in E. coli by making A and B chains separately and joining them by disulphide bonds. So statement 3 is not correct.

Doubtly AI · 30 Oct 2026 AI-generated · not yet verified Report
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